Custom Peptides
Cayman Chemical CyclopentolatehydroCLOrID 10mg
A muscarinic receptor antagonist (Kis = 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively); inhibits carbachol-induced contraction of isolated human iris sphincter, circular ciliary muscle, and longitudinal ciliary muscle (Kbs = 7.9, 15.8, and 12.5 nM, respectively)
Cayman Chemical 1 3DIpalmItol2EIcosapenta 10mg
A triacylglycerol; dietary administration decreases hepatic triacylglycerol levels in mice
Cayman Chemical 1PalmItoyl2Stearoyl3Buty 10mg
A triacylglycerol; has been used to determine the stereospecificity and typoselectivity of lipases
Cayman Chemical RIsutegnIbtrIfluoroacetAT 10mg
An anti-integrin peptide; protects against hydroquinone-induced necrosis and apoptosis, as well as inhibits hydroquinone-induced production of ROS in RPE cells at 400 µM; decreases expression of BAX, VEGFA, and ITB1 in human AMD cybrid cell lines at 20 mg/ml; arrests aberrant blood vessel growth mediated by αVβ3, αVβ5, and α5β1 integrins in vivo
Cayman Chemical N-Alyl- -SKF 38393hydrob 10mg
A dopamine D1 receptor partial agonist; selective for dopamine D1 over D2 receptors in radioligand binding assays (Kis = 302 and 5,250 nM, respectively); reduces food intake in rats (ED50 = 3.6 mg/kg); reduces cocaine and food self-administration in squirrel monkeys from 0.1-10 mg/kg
Cayman Chemical Cornus ofcnals Verbenaln 10mg
An iridoid glucoside; inhibits the activities of COX-1 and COX-2 by 37 and 48%, respectively, at 258 µM; inhibits proliferation of AGS gastric, SF-268 CNS, HCT116 colon, NCI H460 lung, and MCF-7 breast cancer cells at 129 µM; reduces carrageen-induced paw edema and TPA-induced EAr dema in mice; reduces increases in MDA levels and ROS production in isolated brain mitochondria isolated from, as well as decreases infarct volume and neurological deficits in, a rat model of MCAO-induced ischemia-reperfusion injury
Cayman Chemical nagrelIdehydrochlorIde 10mg
A PDE3 inhibitor (IC50 = 36 nM for the human platelet enzyme); inhibits thrombopoietin-induced megakaryocytopoiesis of isolated human CD34+ progenitor cells (IC50 = 26 nM); reduces ADP-, collagen-, thrombin-, or arachidonic acid-induced platelet aggregation in isolated rabbit platelet rich-plasma (EC50s = 0.31, 0.08, 0.18, and 0.1 UG/ml, respectively); inhibits platelet thrombus formation in a dog model of electrically induced carotid artery thrombosis when administered at 0.5-5 mg/kg
Cayman Chemical AdenosIn 5methylendIphosp 10mg
An inhibitor of ecto-5’-nucleotidase (Ki = 37 nM); inhibits AMP-, ADP, or ATP-induced cAMP accumulation in VA-13 human fibroblasts at 100 µM; reduces proliferation of U138MG glioma cells, as well as inhibits the invasion and migration of MHCC97H HCC cells in a migration assay; increases tumor infiltration of CD3+CD8+ T cells and reduces tumor growth in a K1735 murine melanoma model
Cayman Chemical Guafensn 10mg
An analytical reference standard categorized as an expectorant; intended for use in analytical forensic applications
Cayman Chemical PolygalacIc AcId 10mg
A triterpenoid saponin with antioxidant and neuroprotective activities; scavenges peroxyl and peroxynitrite radicals in TOSC assays from 25-200 µM; reverses scopolamine-induced memory deficits, decreases in hippocampal ACh levels, increases in hippocampal IL-1β and IL-10 levels, and decreases in brain SOD and GSH levels in mice at 3, 6, and 12 mg/kg
Cayman Chemical DIhydrochelerythrIn 10mg
An alkaloid with diverse biological activities; active against S. aureus, S. faecalis, and C. albicans (MIC = 1.87 μg/ml for all); inhibits secretion of the HBV antigens HBsAg and HBeAg from HepG2 2.2.15 cells (IC50s = 50s = 1.4, 0.4, and 3.5 μM, respectively)
Cayman Chemical dPE-PolysarcosIn150 10mg
An amine-functionalized hydrophilic polymer; a polysarcosine-labeled form of DSPE; polysarcosines have been used as alternatives to PEGylation in LNPs and to reduce the immunogenicity of administered proteins in vivo
Cayman Chemical Cambendazol 10mg
An antihelmintic agent; eradicates S. ratti adult worms from intestine and S. stercoralis larva from muscle at a dose of 50 mg/kg/day; inhibits polymerization of microtubules isolated from bovine brain (IC50 = 64.2 µM)
Cayman Chemical LK6L9trIfluoroACTAte salt 10mg
A cytolytic peptide; cytotoxic to LNCaP-CL1, 22Rv1, and LNCaP cells (LC50s = 4, 4, and 6 µM, respectively), as well as non-cancerous NIH3T3 and OL cells (LC50s = 7 and 5 µM, respectively); induces hemolysis of isolated human erythrocytes at 100 µM