Custom Peptides
Cayman Chemical Halometason 10mg
Peroxidation of common W-6 PUFAs such as linoleic acid DGLA and arachidonic acid can give rise to 4-HNE 4-HNE is cleared rapidly from the plasma and undergoes enterohepatic circulation as a glutathione conjugate in the rat 7334 About two thirds of an administered dose of 4-HNE is excreted within 48 hours in the urine primarily in the form of mercapturic acid conjugates 8626 The C-1 aldehyde of 4-HNE is reduced to an alcohol in about half of these metabolites The remainder are C-1 aldehydes or have been oxidized to C-1 carboxylic acids These aldehydes and carboxylic acids can also form Y-lactols and Y-lactones respectively producing at least 4 or 5 end urinary metabolites of 4-HNE in vivo
Cayman Chemical CytarabIn 5-monphosphate 10mg
An adenosine A1 receptor agonist selectively binds adenosine A1 over A2A and A3 receptors (Kis 0 85 210 and 281 nM respectively for the rat receptors) increases survival and prevents neuronal damage in the hippocampal CA1 region in a gerbil model of bilateral carotid artery occlusion-induced cerebral ischemia at 75 Ug/kg protects against auditory threshold shifits and inner and outer hair cell loss in rats following noise exposure at 110 dB at 100 Ug/kg
Cayman Chemical 3-epI UrsolIc AcId 10mg
A multi-kinase inhibitor has been used as an affinity ligand for proteomics-based kinome analyses of cancer cells
Cayman Chemical 1 2DIoleoyl3lInoleoylrac 10mg
A macrocyclic depsipeptide anthelmintic inhibits locomotion in C. elegans (IC50 14 nM) an effect that can be reversed by knockout of the gene encoding SLO-1 decreases the survival of N. brasiliensis and S. ratti worms in infected rats and H. polygyrus worms in infected mice at 10 mg/kg
Cayman Chemical JWH 018 adamntyl nalog 10mg
Source Recombinant human N-terminal His- and GST-tagged MRE11 expressed in E. coli Amino acids 1-411 MW 74.7 kDa
Cayman Chemical JWH 018 N 1 2dImthylPRYl 10mg
An AMPA receptor positive allosteric modulator increases glutamate-induced calcium influx in CHO cells expressing human AMPA receptors (EC50 3.3 UM) potentiates AMPA receptor-mediated currents in rat primary hippocampal neurons (EC50 4.4 UM) ameliorates MK-801-induced working memory deficits in the radial arm maze task in rats from 0.1-10 mg/kg increases DMTS accuracy in cynomolgus monkeys at 0.06 mg/kg
Cayman Chemical 2mthylaPyrroldInobutIoph 10mg
A 20S proteasome inhibitor (IC50 ~1 UM) induces the accumulation of ubiquitinated proteins in HCT116 colon cancer cells at 1 UM sensitizes HCT116 p53 / and HCT116 p53-/- cells to ionizing radiation-induced cytotoxicity in an additive and synergistic manner respectively decreases the viability of macrophages isolated from patients with rheumatoid arthritis (IC50 0.88 UM)
Cayman Chemical AtIpamezolehydrochlorIde 10mg
An inhibitor of parasitic PKGs (IC50s 1.9 and 1 nM for the E. tenella and T. gondii enzymes respectively) inhibits P. berghei sporozoite development into liver-stage parasites in HepG2 cells in a concentration-dependent manner prevents P. yoelii liver infection in P. yoelii-infected mice when administered at a dose of 50 mg/kg increases survival time in P. berghei-infected mice at 50 mg/kg twice per day for eight days increases survival in T. gondii-infected mice and prevents secondary reinfection in the same mice at 50 mg/kg two times per day
Cayman Chemical RosIglItazon 10mg
A dipeptide enhances potassium-induced release of L-glutamate and inhibits kainate-induced formation of cGMP in isolated mouse cerebral cortical slices at 0.1 and 1 mM respectively decreases plasma levels of T3 and increases plasma TSH levels in rats at 600 UG/kg prevents electroconvulsive shock-induced amnesia in rats at 50 UG/animal p.o.
Cayman Chemical Decnoyl m-NItronIlIn 10mg
A PDE5A inhibitor (IC50 1.9 nM) improves motor scores in a rat model of MCAO-induced stroke at 10 mg/kg
Cayman Chemical N 3hydroxy7cIs tetradecen 10mg
An orexin receptor 2 antagonist (Ki 10 nM) selective for OX2R over OX1R (Ki 794 nM) and a panel of 50 receptors ion channels and transporters at 1 UM reduces the latency to NREM sleep onset and increases the duration of NREM sleep in rats at 3 10 and 30 mg/kg
Cayman Chemical 4-APDBhydrochlorIde 10mg
An internal standard for the quantification of voriconazole N-oxide by GC- or LC-MS
Cayman Chemical JWH 210 2ethylnaphthyl 10mg
An NLRP3 inflammasome inhibitor inhibits NLRP3 inflammasome by 51.8 at 10 UM inhibits caspase 1 (Ki 10.6 UM) active against S. aureus C. diphtheriae K. pneumoniae and E. coli (MICs 18 18 18 and 16 UG/ml respectively) and the fungus C. albicans (MIC 13 UG/ml) inhibits ATP-induced pyroptosis in PMA-differentiated and LPS-stimulated THP-1 cells at 10 UM induces cytotoxicity in HK-2 cells (IC50 67 UM) inhibits Aß42-induced increases in IL-1ß IL-18 TNF-a and GSDMD in SH-SY5Y cells at 10 UM
Cayman Chemical N 8ZHeptadecen1ylO 3p 10mg
Oliogonucleotide recipes are optimized for Bio-Rad CFX96 or CFX384. Includes 4 tubes Tube 1 5X Primers and probes for 4 pathogens and human control Tube 2 Synthetic positive controls Tube 3 Spike-in RPP30 control Tube 4 2X qPCR enzyme mastermix Organism Type Bacteria (no cell well) Multiplexed Reaction Panels STI Vaginal microbiota Colors Cy5 (Mycoplasma genitalium) Cy5.5 (Ureaplasma urealyticum) FAM (Neisseria gonorrhoeae) HEX (RPP30) TEX615 (Treponema pallidum) Instruments Bio-Rad CFX96 or CFX384